New Discovery Reveals Sex-Specific Causes of Depression Triggered by Stress Hormones Dysfunction - Neuroscience News Men are more likely to have a dysregulated HPA axis that is associated with depressive symptoms, while women have higher levels of binding proteins for stress hormones that may prevent dysregulation of the HPA axis. The findings shed new light on how stress hormones impact dopamine transmission and how this impacts depression on a sex-specific basis.